SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF 1,2,4,5-TETRA SUBSTITUTED IMIDAZOLE

Abstract

This study includes the synthesis, characterization and bioscreening of tetra-substituted imidazole derivatives. This is based on the formation of benzil by the oxidation of benzoin with concentrated nitric acid. The synthesized benzil was used for the preparation of main product tetra tetra-substituted imidazole and its analogues by reacting benzil with ammonium acetate, aniline and different substituted aldehydes in the presence of solvent ethanol, maintaining reflux temperature. Varieties of tetra-substituted imidazole were obtained. Structures of these compounds were confirmed by IR and EIMS. All prepared compounds were screened for antimicrobial activity and they showed influential results such as 2-(2,4-dimethoxyphenyl)-1,4,5-triphenyl-1H-imidazole,2-(2,5-dimethoxyphenyl)-1,4,5-triphenyl-1H-imidazole,1,4,5-triphenyl-2-(2,4,5-trimethoxyphenyl)-1H-imidazole and 1,2,4,5-tetraphenyl-1H-imidazole show potency against microbes.